Investigating the interaction of Gamma-Tocotrienol (GTT) and Hydroxy-chavicol (HC) and its mode of cell death on glioma cell lines.
TOCOTRIENOLS CAN SUPPORTAPOPTOSIS IN GLIOMA CANCER CELLS
Introduction to Glioblastoma, Brain Cancer, and Gamma-TocotrienolGlioblastoma or brain cancer is the 10th leading cause of death for both men and women. Glioblastomas are tumors that are formed of a large portion of tumor cells that keep dividing and reproducing at an alarming rate because they are well-nourished by the abnormal tumor blood supply.
Glioblastomas are very infiltrative and invasive as they invade into other regions of the brain and cause problems. Hence it is very necessary that it should be treated with the help of an agent that can suppress tumor growth and prevent the formation of blood vessels in the tumor (anti-angiogenesis). In this study, the interaction of Gamma-Tocotrienol (GCC) and Hydroxy-chavicol (HC) and its mode of cell death on glioma cell lines was observed.
How does Gamma-Tocotrienol fight Glioblastoma or Brain Cancer?In the study, it was observed that the sub-lethal doses of the combination of Gamma-Tocotrienol (GTT) and Hydroxy-chavicol (HC), greatly suppressed the cell proliferation of glioma cancer cells and exhibited strong synergistic effects. Gamma-Tocotrienol has been observed to exhibit properties like angiogenesis, anti-call proliferation, apoptosis, and anti-inflammation. In this study too, it was observed that GTT along with HC, was able to exert synergistic inhibition of cell proliferation through induction of apoptosis in human glioma cancer cells in vitro.
Reference for the Study in detail:1. https://pubmed.ncbi.nlm.nih.gov/24980711/
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