Eannatto Gamma-Tocotrienol and Simvastatin Synergistically Induce Cytotoxicity In Leukaemia Cancer Cells

Investigating the effects of Gamma-Tocotrienols in combination with Simvastatin on Leukaemia cancer cells.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human blood cancer cells, kindly refer to the reference link provided at the bottom of this abstract.



Introduction to Leukaemia and Gamma-Tocotrienol
Leukemia is a type of blood cancer that is caused when white blood cells in the body start multiplying abnormally in large numbers and start harming the red blood cells and the platelets.
Gamma-Tocotrienols along with statins modulate the cholesterol biosynthesis pathway by inhibiting HMG-CoA reductase by post-transcriptional downregulation. This mechanism leads to cancer cell cycle arrest, apoptosis, and suppression of cancer cell proliferation. Several studies have also shown that statins suppress certain actions of acute myelocytic leukemia cells. Since both gamma-Tocotrienols and Statins, both, are associated with the decrease in cholesterol biosynthesis, hence it was investigated if the combination of these drugs could synergize in cytotoxicity on leukemic cells.
How does Gamma-Tocotrienol fight Leukaemia or Blood Cancer?
In the study, it was observed that both Gamma-Tocotrienol and Simvastatin induced cytotoxicity in K-562 and HL-60 cell lines by the MTS and Cell Titer Glo Assays.
In the study, it was shown that Simvastatin which is a cholesterol-lowering drug, and Gamma-Tocotrienol which is an antioxidant, were together able to exhibit synergy in the induction of cytotoxicity in K-562 and HL-60 leukemia cancer cell lines. All the mechanisms combined resulted in cell cycle arrest, inductions of apoptosis, and suppression of cancer cell proliferation.
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900g of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
Reference for the Study in detail:
1. https://ashpublications.org/blood/article/122/21/4927/14222/Gamma-Tocotrienol-and-Simvastatin-Synergistically
2. https://cancerstatisticscenter.cancer.org/#!/cancer-site/Leukemia
3. https://www.webmd.com/cancer/lymphoma/understanding-leukemia-basics#1
4. R.S. Wong, A.K. Radhakrishnan, T.A. Ibrahim, S.K. Cheong, δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells, Microsc Microanal. 18 (2012) 462-469.
5. R.S. Wong, A.K. Radhakrishnan, T.A. Ibrahim, S.K. Cheong, δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells, Microsc Microanal. 18 (2012) 462-469.
6. A. Inoue, K. Takitani, M. Koh, C. Kawakami, T. Kuno, H. Tamai, Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway, Nutr Cancer. 63 (2011) 763-770
7. C.C. Chen, T.Y. Liu, S.P. Huang, C.T. Ho, T.C. Huang, Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase. Cell Signal. 27 (2015) 2182-2190.
8.M.L. de Mesquita, R.M. Araújo, D.P. Bezerra, R.B. Filho, J.E. de Paula, E.R. Silveira, C. Pessoa, M.O. de Moraes, L.V. Costa Lotufo, L.S. Espindola, Cytotoxicity of δ-tocotrienols from Kielmeyera coriacea against cancer cell lines, Bioorg Med Chem. 19 (2011) 623-630. [

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