Investigating the combined effects of Delta-Tocotrienol and DHA against triple negative breast cancer cells.
TOCOTRIENOLS CAN SUPPORT
ANTI-PROLIFERATIVE EFFECTS IN CANCER CELLS BY INDUCING APOPTOSIS
ANTI-ANGIOGENIC EFFECTS TO KILL CANCER CELLS
INHIBITION OF CELL PROLIFERATION
ANTICANCER CHEMOTHERAPIC EFFECTS
Introduction to Breast Cancer and TocotrienolsAfter lung cancer, Breast cancer is the 2nd most frequent cancer occurring in women and one of the most commonly occurring cancer in the world. Fighting triple negative breast cancer is a major challenge as it has complex biology, shows drug resistance, and does not respond to hormonal activities.
In this study, the individual and combined effects of an incredibly rare isomer of Vitamin-E, Delta-Tocotrienol and DHA on tumor growth reduction with conventional therapies was investigated. Tocotrienols are specific isomers of vitamin E that have been shown to help reduce inflammation and oxidative stress in chronic disease. Also, isomers of Tocotrienols, especially, the Delta and gamma isomers, have superior antioxidant, anti-inflammatory, and anticancer, and effects compared to the Tocopherol isomers. DHA has been used successfully as an adjunct to cancer treatments, increasing their efficacy without adverse effects.
How does Tocotrienol fight Breast Cancer?In this study, it was observed that Delta-Tocotrienols and DHA triggered a reduction in the lipid droplet biosynthesis which is a marker of aggressiveness of breast cancer. Although DHA, alone failed to produce any results, but in combination with Delta-Tocotrienol did produce very significant results. It has been estimated that the results of this study may be beneficial against the triple negative breast cancer. The cell proliferation of the breast cancer cells can be suppressed through lipid droplet modulation, thus suppressing the aggressiveness of the cancer. Delta-Tocotrienol, being an antioxidant and an anti-inflammatory agent, helps reduce reactive oxygen species while DHA has been observed to produce reactive oxygen species in breast cancer cells. This further proves that Delta-Tocotrienols can modulate the DHA’s effects on lipid droplet biogenesis.
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