Latest Research Demonstrates Incredible Effects Of Eannatto Delta-Tocotrienols Against Breast Cancer Cells

Investigating the combined effects of Delta-Tocotrienol and DHA against triple negative breast cancer cells.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.
TOCOTRIENOLS CAN SUPPORT


ANTI-PROLIFERATIVE EFFECTS IN CANCER CELLS BY INDUCING APOPTOSIS

ANTI-ANGIOGENIC EFFECTS TO KILL CANCER CELLS

INHIBITION OF CELL PROLIFERATION

ANTICANCER CHEMOTHERAPIC EFFECTS
Introduction to Breast Cancer and Tocotrienols
After lung cancer, Breast cancer is the 2nd most frequent cancer occurring in women and one of the most commonly occurring cancer in the world. Fighting triple negative breast cancer is a major challenge as it has complex biology, shows drug resistance, and does not respond to hormonal activities.
In this study, the individual and combined effects of an incredibly rare isomer of Vitamin-E, Delta-Tocotrienol and DHA on tumor growth reduction with conventional therapies was investigated. Tocotrienols are specific isomers of vitamin E that have been shown to help reduce inflammation and oxidative stress in chronic disease. Also, isomers of Tocotrienols, especially, the Delta and gamma isomers, have superior antioxidant, anti-inflammatory, and anticancer, and effects compared to the Tocopherol isomers. DHA has been used successfully as an adjunct to cancer treatments, increasing their efficacy without adverse effects.
How does Tocotrienol fight Breast Cancer?
In this study, it was observed that Delta-Tocotrienols and DHA triggered a reduction in the lipid droplet biosynthesis which is a marker of aggressiveness of breast cancer. Although DHA, alone failed to produce any results, but in combination with Delta-Tocotrienol did produce very significant results. It has been estimated that the results of this study may be beneficial against the triple negative breast cancer. The cell proliferation of the breast cancer cells can be suppressed through lipid droplet modulation, thus suppressing the aggressiveness of the cancer. Delta-Tocotrienol, being an antioxidant and an anti-inflammatory agent, helps reduce reactive oxygen species while DHA has been observed to produce reactive oxygen species in breast cancer cells. This further proves that Delta-Tocotrienols can modulate the DHA’s effects on lipid droplet biogenesis.
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900g of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oi
Reference for the Study in detail:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250526/
2. Abdul Hafid SR, Radhakrishnan AK, Nesaretnam K (2010) Tocotrienols are good adjuvants for developing cancer vaccines. Cancer 10 (Article in press) [PMC free article] [PubMed]
3. Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, Kerin MJ. Estrogen receptor α and β profiling in human breast cancer. J Cancer Surg. 2004;30:469–474. [PubMed] [Google Scholar]
4. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 94, 153–156.
5. Hisham AN, Yip CH (2004) Overview of breast cancer in Malaysian women: a problem with late diagnosis. Asian J Surg. 27, 130–133.
6. Hisham AN, Yip CH (2003) Spectrum of breast cancer in Malaysian women: overview. World J. Surg. 27, 921–923.
7. Kaufman HL, Wadler S, Antman K (2011) Molecular Targeting in Oncology (Cancer Drug Discovery and Development). Humana Press., Totowa, Nj: 1617376531.
8. Ricci MS, Wei-Xing Z (2006) Chemotherapeutic approaches for targeting cell death pathways. Oncologist 11, 342–357.
9. Fulda S, Gorman Am, Hori O, Samali A (2010) Cellular stress responses: cell survival and cell death. Int. J. Cell Biol. 2010, Article ID 214074, 1–23; doi:10.1155/2010/214074

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