Investigating a novel function of Vitamin E Delta-Tocotrienol (VEDT) with TRAIL of inducing apoptosis in Pancreatic Cancer Cells.
TOCOTRIENOLS CAN SUPPORTINDUCTION OF APOPTOSIS
DEGRADATION AND REDUCTION OF c-FLIP LEVELS
CHEMOPREVENTION AND THERAPEUTIC EFFECTS AGAINST CANCERS
Introduction to Pancreatic Cancer and Delta-TocotrienolThe pancreatic cancer is one of the deadliest cancers. The worrisome fact regarding this cancer is that it is very difficult to diagnose because this cancer has no symptoms. If found at the early stages, then the tumor can be removed and the life expectancy can be increased but since the prognosis isn’t easy, cancer spreads quite fast, and hence, the 5-year survival rate is just 9%.
In this study, a novel function of Delta-Tocotrienol in augmenting tumor necrosis factor-related apoptosis-inducing gland (TRAIL) induced apoptosis or programmed cell death in pancreatic cancer cells was demonstrated.
How does the Delta-Tocotrienol fight Pancreatic cancer?It was observed in the study that, when VEDT was combined with TRAIL, it significantly augmented TRAIL-induced apoptosis in the pancreatic cancer cells. Delta-Tocotrienols was also observed to significantly decrease the cellular FLICE inhibitory protein (c-FLIP) levels. It has been observed that the expression of c-FLIP suppresses the apoptosis mechanism induced by the combination of VEDT and TRAIL. Hence, the reduction of c-FLIP expression is very necessary.
Also, it was demonstrated that Delta-Tocotrienol increased c-FLIP degradation and ubiquitination without affecting its transcription. Hence, it can be concluded that Delta-Tocotrienol decreases c-FLIP levels while degrading it.
Reference for the Study in detail:1. https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0876-0
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