Investigating the effects of Delta-Tocotrienol on Pancreatic Ductal Adenocarcinoma
TOCOTRIENOLS CAN SUPPORTPREVENTION OF METASTASES
INHIBITION OF STEM CELLS
INHIBITION OF INVASION AND MIGRATION OF CANCER CELLS
Introduction to Pancreatic Cancer and Delta-TocotrienolPancreatic adenocarcinoma is the most common type of pancreatic cancer and they usually start from the duct of the pancreas. The worrisome fact regarding this cancer is that it is very difficult to diagnose because this cancer has no symptoms.
In this study, it has been shown that Delta-Tocotrienol is a natural bioactive against cancer, prevents metastases, and delays progression in transgenic mouse models of pancreatic ductal adenocarcinoma. The striking feature of this study is that it has given the first evidence of Delta-Tocotrienol inhibits PDAC stem cells!
How does the Delta-Tocotrienol fight Pancreatic cancer?In this study, it has been observed that Delta-Tocotrienols prevents metastases and delays progression in transgenic mouse models of pancreatic ductal adenocarcinoma. Also, in this study, the first evidence of Delta-Tocotrienols selectively inhibiting PDAC stem-like cells was demonstrated.
It was also observed that Delta-Tocotrienol inhibited the invasion, migration, and several biomarkers of epithelial to mesenchymal transition. Delta-Tocotrienol also suppressed angiogenesis, the process of formation of blood vessels in cancer cells, in the PDAC cells and tumors thus suppressing tumor growth and the spread of cancer.
In an orthotopic xenograft model of human pancreatic ductal adenocarcinoma cells, it was observed that Delta-Tocotrienols incredibly suppressed the growth and metastases of the PDAC human stem-like cells which were even resistant to the anti-cancer drug, gemcitabine! Hence, it can be concluded that Delta-Tocotrienol can help in chemoprevention of PDAC metastases.
Reference for the Study in detail:1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458229/
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