Eannatto δ-Tocotrienol, the Most Potent Form of vitamin E, Inhibits Pancreatic Cancer Stem-like Cells and Prevents Pancreatic Cancer Metastasis

Investigating the effects of Delta-Tocotrienol on Pancreatic Ductal Adenocarcinoma
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human pancreatic cancer cells, kindly refer to the reference link provided at the bottom of this abstract.
TOCOTRIENOLS CAN SUPPORT
PREVENTION OF METASTASES

ANTI-ANGIOGENESIS

INHIBITION OF STEM CELLS

INHIBITION OF INVASION AND MIGRATION OF CANCER CELLS
Introduction to Pancreatic Cancer and Delta-Tocotrienol
Pancreatic adenocarcinoma is the most common type of pancreatic cancer and they usually start from the duct of the pancreas. The worrisome fact regarding this cancer is that it is very difficult to diagnose because this cancer has no symptoms.
In this study, it has been shown that Delta-Tocotrienol is a natural bioactive against cancer, prevents metastases, and delays progression in transgenic mouse models of pancreatic ductal adenocarcinoma. The striking feature of this study is that it has given the first evidence of Delta-Tocotrienol inhibits PDAC stem cells!
How does the Delta-Tocotrienol fight Pancreatic cancer?
In this study, it has been observed that Delta-Tocotrienols prevents metastases and delays progression in transgenic mouse models of pancreatic ductal adenocarcinoma. Also, in this study, the first evidence of Delta-Tocotrienols selectively inhibiting PDAC stem-like cells was demonstrated.
It was also observed that Delta-Tocotrienol inhibited the invasion, migration, and several biomarkers of epithelial to mesenchymal transition. Delta-Tocotrienol also suppressed angiogenesis, the process of formation of blood vessels in cancer cells, in the PDAC cells and tumors thus suppressing tumor growth and the spread of cancer.
In an orthotopic xenograft model of human pancreatic ductal adenocarcinoma cells, it was observed that Delta-Tocotrienols incredibly suppressed the growth and metastases of the PDAC human stem-like cells which were even resistant to the anti-cancer drug, gemcitabine! Hence, it can be concluded that Delta-Tocotrienol can help in chemoprevention of PDAC metastases.
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-1600mg of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
Reference for the Study in detail:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458229/
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