Cardiovascular diseases (CVDs) are the number 1 cause of death globally. An estimated 17.9 million people died from cardiovascular diseases in 2016 representing 31% of all global deaths in 2016. Out of these, 85% were due to heart attack and stroke. According to the American Heart Association, a new clinical study has suggested that Tocotrienols from Annatto may enhance cardiovascular benefits. A Canadian company, Eannatto has successfully harvested Annatto for Tocotrienols to deliver it to every corner of the world to provide maximum health benefits.
Cholesterol reduction is a significant feature of Tocotrienols by suppression of HMGR (3-hydroxy3methyl-glutaryl-CoA reductase) the enzyme/protein responsible for the body’s cholesterol production.
Cytokines associated with cardiovascular diseases were down-regulated by Tocotrienols according to the study done at the University of Missouri – Kansas City.
MicroRNAs which are usually down-regulated in hyper-cholesterolemic individuals are up-regulated by Tocotrienol treatment as per the study.
Cellular adhesion molecule expression has been observed to be reduced by Tocotrienols.
Monocytic cell adherence has also been found to be reduced by Tocotrienol in multiple kinds of research
‘Velcro effect”, a process which initiates plaque formation in arterial walls has also been observed to be reduced by Tocotrienol.
Lipid peroxides in blood vessels and blood pressure have been observed to be lowered by Tocotrienols which improves total anti-oxidant status thus preventing hypertension.
Carotid Arteriosclerosis has been observed to be reduced by Tocotrienol in several studies.
Anti-inflammation are characteristic properties of Tocotrienols.
In several studies, 100 mg/day of Tocotrienols was found effective for cholesterol and triglyceride reduction. However, the dosage varies for different CVDs.
Why Tocotrienol and Not Tocopherol?
Ineffective Tocopherol Large clinical studies on alpha-tocopherol have shown it to be ineffective and possibly harmful. Also, Tocopherols do not have the cholesterol-lowering ability which Tocotrienols do.
The inability of Tocopherol to regulate Cholesterol Synthesis: While Tocopherol has antioxidant value, they lack the ability to regulate cholesterol synthesis.
Structure of Tocotrienol: Tocotrienol has a smaller structure and less molecular weight which helps it to move freely through the cell membranes to cover larger areas for added protection.
Tocopherol, the enemy of Tocotrienol: Alpha-tocopherol has been observed to attenuate or interfere with the cholesterol-lowering function of Tocotrienols. Preparations effective in cholesterol-lowering action consist of 15% or less of alpha-tocopherol and 60% or more gamma and delta Tocotrienols while ineffective preparations consist of 20% or more alpha-tocopherol and 45% or less of gamma and delta-tocotrienols.
Absorption: As compared to Tocopherols, Tocotrienols absorb better in the body and Tocopherols have been observed to prevent absorption of Tocotrienols.
- World Health Organization: Cardiovascular diseases https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
- Tocotrienols: Vitamin E for Cardiovascular benefits after all by Barrie Tan, Ph.D., and Anne M. Trias, MS.