Cell Proliferation is the process by which cancer cells copy their DNA and divide into two cancer cells during mitosis and rapidly multiply into more cancer cells. It was observed that Delta-Tocotrienol inhibited lung cancer cell proliferation, induce cancer cell death and prevented cell cancer invasion.
Chemopreventionand anti-cancer activity against lung cancer have been observed in Tocotrienols. Delta-Tocotrienol was observed to exert anti-cancer activity in lung cancer by elevating microRNA, miR-34a, that led to the downregulation of Notch-1 and its downstream targets such as Bcl-2, cyclin D1, and survivin. Moreover, it was also observed that a redox-silent analogue of Alpha-Tocotrienol, 6-O-carboxypropyl-alpha-tocotrienol was found to possess higher anti-cancer potential than Tocotrienol in A549 lung cancer cells.